Dr. James C. Karegeannes [Care-ah-gene-us] graduated magna cum laude from the University of South Carolina Honors Program. In addition to being named a National Merit Scholar, he was also a member of Phi Beta Kappa. He completed medical school at Duke University. Dr. Karegeannes completed his internship at the San Diego Naval Hospital. This was followed by three years as a Submarine and Diving Medical Officer in the Navy.
Dr. James C. Karegeannes [Care-ah-gene-us] graduated magna cum laude from the University of South Carolina Honors Program. In addition to being named a National Merit Scholar, he was also a member of Phi Beta Kappa. He completed medical school at Duke University. Dr. Karegeannes completed his internship at the San Diego Naval Hospital. This was followed by three years as a Submarine and Diving Medical Officer in the Navy.
The reviews listed below were collected independently of EmergeOrtho through rater8. Each review represents an authentic and verified patient experience.
Very friendly staff, Dr. Karegennes has been my Doctor for twenty years. Replacing both my hip joints. He’s the best !!!
(6 days ago)
Dec-2025
Exceptional doctor.
(2 weeks ago)
Dec-2025
He's patient focused and is so competent
(2 weeks ago)
Dec-2025
Dr kerehgrannes is great.
Put my mind at ease
(2 weeks ago)
Dec-2025
Dr. K replaced one knee, and it is now perfect. He replace a 1960's football inured knee. It was iin bad shape.
Now, I'm going to have him replace the other one because of old age and arthritis. He is an excellent orthopedic doctor.
(2 weeks ago)
Dec-2025
Everything about this surgery went beautifully.And I wish I had done this two years ago. Excellent care from the doctor's staff and the hospital.No complaints whatsoever. Thank you Dr Karegeannes. Sue Garrison
(2 weeks ago)
Dec-2025
Very confident in him and his doctrine with my bilateral knee problems. He always gives me his recommendations and explains why.
(3 weeks ago)
Dec-2025
Very caring… excellent “bedside manner”…has good solutions to problems…
(1 month ago)
Nov-2025
Appreciate his talent and skills.
(1 month ago)
Nov-2025
It’s always a pleasure dealing with Dr. Karegeannes.
(1 month ago)
Nov-2025
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Blue Ridge Region: Asheville - McDowell - Orthopedics
129 McDowell Street Asheville, NC 28801
Dr. James C. Karegeannes [Care-ah-gene-us] graduated magna cum laude from the University of South Carolina Honors Program. In addition to being named a National Merit Scholar, he was also a member of Phi Beta Kappa. He completed medical school at Duke University. Dr. Karegeannes completed his internship at the San Diego Naval Hospital. This was followed by three years as a Submarine and Diving Medical Officer in the Navy. He then returned to Duke for his Orthopedic Surgery Training followed by a Hip and Knee Replacement Fellowship at The Hospital for Special Surgery in New York City.
He specializes in hip and knee replacement surgery, as well as revision surgery for failed replacements. He performs more than 450 joint replacement surgeries per year. He was named one of the “Top Doctors” for Hip and Knee Arthroplasty, Money magazine, Special Report, “The Best Health Care in America”, in fall 2003. He reviews articles the Journal of Arthroplasty and cases for the North Carolina Medical Board. He is currently the chief of the Orthopedic service line at Mission HCA hospital in Asheville.
He is active in local and national joint replacement organizations to help ensure that patients in our region can access the latest treatment options. He does not accept consulting fees or other payments from joint implant manufacturers to ensure his recommendations for treatment are unbiased and place his patients’ interests first.
Outside the office, he enjoys spending time with his wife, two adult children and one large hound dog. He serves on the local Boy Scout council executive board, enjoys hiking, gardening and burrowing into old books on food and drink culture.
Very friendly staff, Dr. Karegennes has been my Doctor for twenty years. Replacing both my hip joints. He’s the best !!!
Exceptional doctor.
He's patient focused and is so competent
Dr kerehgrannes is great. Put my mind at ease
Dr. K replaced one knee, and it is now perfect. He replace a 1960's football inured knee. It was iin bad shape. Now, I'm going to have him replace the other one because of old age and arthritis. He is an excellent orthopedic doctor.
Everything about this surgery went beautifully.And I wish I had done this two years ago. Excellent care from the doctor's staff and the hospital.No complaints whatsoever. Thank you Dr Karegeannes. Sue Garrison
Very confident in him and his doctrine with my bilateral knee problems. He always gives me his recommendations and explains why.
Very caring… excellent “bedside manner”…has good solutions to problems…
Appreciate his talent and skills.
It’s always a pleasure dealing with Dr. Karegeannes.