Dr. James C. Karegeannes [Care-ah-gene-us] graduated magna cum laude from the University of South Carolina Honors Program. In addition to being named a National Merit Scholar, he was also a member of Phi Beta Kappa. He completed medical school at Duke University. Dr. Karegeannes completed his internship at the San Diego Naval Hospital. This was followed by three years as a Submarine and Diving Medical Officer in the Navy.
Dr. James C. Karegeannes [Care-ah-gene-us] graduated magna cum laude from the University of South Carolina Honors Program. In addition to being named a National Merit Scholar, he was also a member of Phi Beta Kappa. He completed medical school at Duke University. Dr. Karegeannes completed his internship at the San Diego Naval Hospital. This was followed by three years as a Submarine and Diving Medical Officer in the Navy.
The reviews listed below were collected independently of EmergeOrtho through rater8. Each review represents an authentic and verified patient experience.
Efficient office. Everyone cheerful
(2 weeks ago)
Sep-2026
He was very friendly and knowledgeable.
(2 weeks ago)
Sep-2026
Dr. Karegeannes has a professional way to make sure that you are taken care of. He listens and makes sure that your health is first and foremost a priority. Thanks Dr. K and I have passed his name to neighbors in my community.
(3 weeks ago)
Aug-2026
Dr. Karegeannes explained everything to me thoroughly. He spent a good amount of time with me, explaining how the procedure would be performed, why he recommended doing it in a particular way, and what I could expect during my recovery.
(1 month ago)
Aug-2026
Listens-very reasonable and uncomplicated- caring
(1 month ago)
Aug-2026
Dr. Karegeannes did my full left hip replacement in 2025 and I just met with him again to sort out another issue. I’m very grateful for what he has done for me and the quality of my life too. I’ve recommended him to friends quite a few times already.
(1 month ago)
Aug-2026
Takes time to explain!
(1 month ago)
Aug-2026
Very knowledgeable and caring
(1 month ago)
Aug-2026
Awesome doctor
(1 month ago)
Aug-2026
Timely, explained everything
(1 month ago)
Aug-2026
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Blue Ridge Region: Asheville - McDowell - Orthopedics
129 McDowell Street Asheville, NC 28801
Dr. James C. Karegeannes [Care-ah-gene-us] graduated magna cum laude from the University of South Carolina Honors Program. In addition to being named a National Merit Scholar, he was also a member of Phi Beta Kappa. He completed medical school at Duke University. Dr. Karegeannes completed his internship at the San Diego Naval Hospital. This was followed by three years as a Submarine and Diving Medical Officer in the Navy. He then returned to Duke for his Orthopedic Surgery Training followed by a Hip and Knee Replacement Fellowship at The Hospital for Special Surgery in New York City.
He specializes in hip and knee replacement surgery, as well as revision surgery for failed replacements. He performs more than 450 joint replacement surgeries per year. He was named one of the “Top Doctors” for Hip and Knee Arthroplasty, Money magazine, Special Report, “The Best Health Care in America”, in fall 2003. He reviews articles the Journal of Arthroplasty and cases for the North Carolina Medical Board. He is currently the chief of the Orthopedic service line at Mission HCA hospital in Asheville.
He is active in local and national joint replacement organizations to help ensure that patients in our region can access the latest treatment options. He does not accept consulting fees or other payments from joint implant manufacturers to ensure his recommendations for treatment are unbiased and place his patients’ interests first.
Outside the office, he enjoys spending time with his wife, two adult children and one large hound dog. He serves on the local Boy Scout council executive board, enjoys hiking, gardening and burrowing into old books on food and drink culture.
Efficient office. Everyone cheerful
He was very friendly and knowledgeable.
Dr. Karegeannes has a professional way to make sure that you are taken care of. He listens and makes sure that your health is first and foremost a priority. Thanks Dr. K and I have passed his name to neighbors in my community.
Dr. Karegeannes explained everything to me thoroughly. He spent a good amount of time with me, explaining how the procedure would be performed, why he recommended doing it in a particular way, and what I could expect during my recovery.
Listens-very reasonable and uncomplicated- caring
Dr. Karegeannes did my full left hip replacement in 2025 and I just met with him again to sort out another issue. I’m very grateful for what he has done for me and the quality of my life too. I’ve recommended him to friends quite a few times already.
Takes time to explain!
Very knowledgeable and caring
Awesome doctor
Timely, explained everything