Dr. James Killeffer, M.D. is Board Certified by the American Board of Neurological Surgery and is a Fellow of the American Association of Neurological Surgeons. He completed medical school at the University of Tennessee in Memphis, completed a general surgery internship at the University of Tennessee Graduate School of Medicine, and completed his neurosurgical residency at West Virginia University, where he joined their faculty as an Instructor in Neurosurgery.
Dr. James Killeffer, M.D. is Board Certified by the American Board of Neurological Surgery and is a Fellow of the American Association of Neurological Surgeons. He completed medical school at the University of Tennessee in Memphis, completed a general surgery internship at the University of Tennessee Graduate School of Medicine, and completed his neurosurgical residency at West Virginia University, where he joined their faculty as an Instructor in Neurosurgery.
The reviews listed below were collected independently of Neurosurgical Associates, P.C. through rater8. Each review represents an authentic and verified patient experience.
Great doctor; caring and lkind.
Would recommend Dr Killiffer to anyone with spinal problems.
(3 days ago)
Aug-2026
Great Doctor/ person he could explain what was wrong in a way you could understand and took the time to answer all my questions
(6 days ago)
Aug-2026
Did not see him
(1 week ago)
Aug-2026
So kind and thorough!
(4 months ago)
Apr-2026
Dr. Killeffer is conservative on diagnosis and treatment. He was kind, thorough, listened well, offered solutions and didnt rush my questions. He reputation stands to be exemplary!
(4 months ago)
Mar-2026
Was very helpful. Answers my question. Would recommend him to anyone who needs his care.
(4 months ago)
Mar-2026
One of the best doctors I have met
(4 months ago)
Mar-2026
Excellent in every respect
(5 months ago)
Mar-2026
Very pleasant and talked in terms easily understood. In a couple of short visits I totally trust Dr Killifer with repairing my neck issues.
(6 months ago)
Feb-2026
A caring caring doctor we need more of dr killefer in this world
(10 months ago)
Sep-2025
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UT Office
1932 Alcoa Hwy Bldg. C, Suite 360 Knoxville, TN 37920
Dr. James Killeffer, M.D. has practiced neurosurgery in Knoxville since 1997. He is Board Certified by the American Board of Neurological Surgery and is a Fellow of the American Association of Neurological Surgeons. He grew up in Knoxville and graduated from the University of Tennessee with Honors in 1987. He completed medical school at the University of Tennessee in Memphis, completed a general surgery internship at the University of Tennessee Graduate School of Medicine, and completed his neurosurgical residency at West Virginia University, where he joined their faculty as an Instructor in Neurosurgery. He returned to Knoxville to join his father in practice at University Neurosurgery, PC.
Dr. Killeffer became a full-time member of the faculty of the University of Tennessee Graduate School of Medicine in 2006. His duties there as Chief of the Division of Neurosurgery and Assistant Professor of Surgery include directing resident and medical student education and participating in neurosurgery-related research.
He has published articles on numerous topics including cervical spine anatomy, spinal imaging, intracranial subdural hematoma, brain tumors, spinal anomalies, intravenous nutrition, and the socio-economic aspects of neurosurgery. Currently, he is collaborating with members of the Engineering Department at the University of Tennessee and with engineers in the private sector in research involving cerebrospinal fluid flow dynamics and the kinematics of brain trauma. He also is working with engineers to develop implants to improve the treatment of cerebrospinal fluid circulation disorders.
Dr. Killeffer’s clinical practice includes treatment of a broad spectrum of adult neurosurgical problems including the brain, spine, and peripheral nerve surgery. Special interests include minimally invasive techniques in brain and spinal surgery, endoscopic pituitary surgery, trigeminal neuralgia, and hemifacial spasm, and surgical neuro-oncology, including brain and spinal stereotactic radiosurgery. He practices at an academic teaching hospital to give his patients access to the state-of-the-art comprehensive care of neurosurgical problems.
See other doctors in Neurosurgical Associates, P.C.
Great doctor; caring and lkind. Would recommend Dr Killiffer to anyone with spinal problems.
Great Doctor/ person he could explain what was wrong in a way you could understand and took the time to answer all my questions
Did not see him
So kind and thorough!
Dr. Killeffer is conservative on diagnosis and treatment. He was kind, thorough, listened well, offered solutions and didnt rush my questions. He reputation stands to be exemplary!
Was very helpful. Answers my question. Would recommend him to anyone who needs his care.
One of the best doctors I have met
Excellent in every respect
Very pleasant and talked in terms easily understood. In a couple of short visits I totally trust Dr Killifer with repairing my neck issues.
A caring caring doctor we need more of dr killefer in this world